期刊
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
卷 35, 期 7, 页码 615-624出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1358468
关键词
local vibration; bone; microstructure; tendon; muscle
资金
- National Natural Science Foundation of China [31170897]
- Nationnal Basic Research Program of China [2011CB710901]
We investigated the effects of vibration (35 Hz, 45 Hz and 55 Hz) as countermeasure locally applied to unloading hind limbs on bone, muscle and Achilles tendon. 40 female Sprague Dawley rats were divided into 5 groups (n = 8, each): tailsuspension (TS), TS plus 35 Hz/0.3 g vibration (TSV35), TS plus 45 Hz/0.3 g vibration (TSV45), TS plus 55 Hz/0.3 g vibration (TSV55) and control (CON). After 21 days, bone mineral density (BMD) and the microstructure of the femur and tibia were evaluated by mu CT in vivo. The biome-chanical properties of the femur and Achilles tendon were determined by a materials testing system. Ash weight of bone, isotonic contraction and wet weight of soleus were also inves-tigated. 35 Hz and 45 Hz localized vibration were able to significantly ameliorate the decrease in trabecular BMD (expressed as the percentage change from TS, TSV35: 48.11 %, TSV45: 31.09 %), microstructure and ash weight of the femur and tibia induced by TS. Meanwhile, 35 Hz vibration significantly improved the biomechanical properties of the femur (57.24 % bending rigidity and 41.66 % Young's modulus vs. TS) and Achilles tendon (45.46 % maximum load and 66.67 % Young's modulus vs. TS). Additionally, Young's modulus of the femur was highly correlated with microstructural parameters. Localized vibration was useful for counteracting microgravity-induced musculoskeletal loss. In general, the efficacy of 35 Hz was better than 45 Hz or 55 Hz in tail-suspended rats.
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