期刊
INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH
卷 28, 期 9, 页码 1169-1182出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0278364908104855
关键词
nanorobots; bacteria; medical robotics; MRI; target chemotherapy; blood vessels
类别
资金
- Canada Research Chair (CRC) in Micro/Nanosystem Development, Fabrication and Validation
- National Sciences and Engineering Research Council of Canada (NSERC)
- Province of Quebec
- Canada Foundation for Innovation (CFI)
- National Institute of Biomedical Imaging and Bioengineering [R21EB007506]
Medical nanorobotics exploits nanometer-scale components and phenomena with robotics to provide new medical diagnostic and interventional tools. Here, the architecture and main specifications of a novel medical interventional platform based on nanorobotics and nanomedicine, and suited to target regions inaccessible to catheterization, are described. The robotic platform uses magnetic resonance imaging (MRI) for feeding back information to a controller responsible for the real-time control and navigation along pre-planned paths in the blood vessels of untethered magnetic carriers, nanorobots, and/or magnetotactic bacteria (MTB) loaded with sensory or therapeutic agents acting like a wireless robotic arm, manipulator, or other extensions necessary to perform specific remote tasks. Unlike known magnetic targeting methods, the present platform allows us to reach locations deep in the human body while enhancing targeting efficacy using real-time navigational or trajectory control. We describe several versions of the platform upgraded through additional software and hardware modules allowing enhanced targeting efficacy and operations in very difficult locations such as tumoral lesions only accessible through complex microvasculature networks.
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