期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 47, 期 11, 页码 925-931出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmv094
关键词
fucoidan; diffuse large B cell lymphoma; cell cycle; apoptosis
资金
- National Natural Science Foundation of China [81372391, 31271496]
- Shanghai Tenth People's Hospital Funds [040113015]
Fucoidan is one of the major sulfated polysaccharides isolated from brown seaweeds. In this study, we determined the anti-cancer activity of fucoidan on diffuse large B cell lymphoma (DLBCL) cells both in vitro and in vivo. Fucoidan inhibited the growth of DLBCL cells in a dose-and time-dependent manner, and fucoidan treatment provoked G(0)/G(1) cell cycle arrest, which was accompanied by p21 up-regulation and cyclin D1, Cdk4, and Cdk6 down-regulation. Fucoidan also induced caspase-dependent cell apoptosis in DLBCL cell lines and primary DLBCL cell. In addition, fucoidan treatment caused the loss of mitochondrial membrane potential and the release of cytochrome c and apoptosis-inducing factor from the mitochondria into the cytosol. Fucoidan also potentiated the activities of carfilzomib in killing DLBCL cells. Oral administration of fucoidan effectively inhibited tumor growth in xenograft mouse models. Our findings reveal the novel function of fucoidan as an anti-DLBCL agent, which can be used in the clinical treatment of DLBCL.
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