期刊
MOLECULAR DIVERSITY
卷 20, 期 1, 页码 299-344出版社
SPRINGER
DOI: 10.1007/s11030-015-9629-8
关键词
Spiroheterocyclic systems; Isatin; Oxindoles; Multicomponent reactions (MCRs); Cycloadditions; Highly functionalised molecules; Diversity-oriented synthesis; DOS
Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.
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