期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 47, 期 3, 页码 207-213出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmu135
关键词
resveratrol; anti-inflammatory; high-mobility group box 1; NF-kappa B; JAK/STAT
资金
- National Natural Science Foundation of China [81273678]
- Foundation of Zhejiang Traditional Chinese Medicine Projects [2013ZQ016]
Resveratrol, the most important ingredient extracted from Polygonum cuspidatum, exerts cytoprotective effects via anti-inflammatory actions in vitro. In this study, we investigated this effect of resveratrol on the lipopolysaccharide (LPS)-induced inflammatory response and its underlying molecular mechanism of action in RAW264.7 murine macrophages. Results showed that resveratrol down-regulated the expression of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), therefore, suppressed the production of nitric oxide and the secretion of IL-6 in LPS-stimulated RAW264.7 cells in a dose-dependent manner. Resveratrol also inhibited the translocation of high-mobility group box 1 (HMGB1) from the nucleus to the cytoplasm and of nuclear transcription factor kappa-B (NF-kappa B) p65 from the cytoplasm to the nucleus; it suppressed the phosphorylation of I kappa B alpha. Furthermore, these actions were mediated by suppressing the phosphorylation of signal transducer and activator of transcription (STAT)-1 and -3. In conclusion, these data indicate that resveratrol exerts anti-inflammatory effects, at least in part by reducing the release of HMGB1 and modulating the NF-kappa B and Janus kinase/STAT signaling pathways. Resveratrol could potentially be developed as a useful agent for the chemoprevention of inflammatory diseases.
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