期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 83, 期 3, 页码 E437-E444出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2011.12.085
关键词
Radioembolization; Holmium microspheres; Dosimetry; Magnetic resonance imaging; Radiation-absorbed dose
资金
- Dutch Technology Foundation STW [06648, 11936]
Purpose: To investigate the potential of magnetic resonance imaging (MRI) for accurate assessment of the three-dimensional Ho-166 activity distribution to estimate radiation-absorbed dose distributions in Ho-166-loaded poly (L-lactic acid) microsphere (Ho-166-PLLA-MS) liver radioembolization. Methods and Materials: MRI, computed tomography (CT), and single photon emission CT (SPECT) experiments were conducted on an anthropomorphic gel phantom with tumor-simulating gel samples and on an excised human tumor-bearing liver, both containing known amounts of Ho-166-PLLA-MS. Three-dimensional radiation-absorbed dose distributions were estimated at the voxel level by convolving the Ho-166 activity distribution, derived from quantitative MRI data, with a Ho-166 dose point-kernel generated by MCNP (Monte Carlo N-Particle transport code) and from Medical Internal Radiation Dose Pamphlet 17. MRI-based radiation-absorbed dose distributions were qualitatively compared with CT and autoradiography images and quantitatively compared with SPECT-based dose distributions. Both MRI- and SPECT-based activity estimations were validated against dose calibrator measurements. Results: Evaluation on an anthropomorphic phantom showed that MRI enables accurate assessment of local Ho-166-PLLA-MS mass and activity distributions, as supported by a regression coefficient of 1.05 and a correlation coefficient of 0.99, relating local MRI-based mass and activity calculations to reference values obtained with a dose calibrator. Estimated MRI-based radiation-absorbed dose distributions of Ho-166-PLLA-MS in an ex vivo human liver visually showed high correspondence to SPECT-based radiation-absorbed dose distributions. Quantitative analysis revealed that the differences in local and total amounts of Ho-166-PLLA-MS estimated by MRI, SPECT, and the dose calibrator were within 10%. Excellent agreement was observed between MRI- and SPECT-based dose-volume histograms. Conclusions: Quantitative MRI was demonstrated to provide accurate three-dimensional Ho-166-PLLA-MS activity distributions, enabling localized intrahepatic radiation-absorbed dose estimation by convolution with a Ho-166 dose point-kernel for liver radioembolization treatment optimization and evaluation. (C) 2012 Elsevier Inc.
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