4.7 Article

PROGNOSTIC VALUE OF PREVERTEBRAL SPACE INVOLVEMENT IN NASOPHARYNGEAL CARCINOMA BASED ON INTENSITY-MODULATED RADIOTHERAPY

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2010.11.063

关键词

Nasopharyngeal carcinoma; Prevertebral space; Intensity-modulated radiotherapy; Magnetic resonance imaging; Prognosis

资金

  1. Science Foundation of Key Hospital of Ministry of Health P.R. China [2007-353]
  2. Hi-Tech Research and Development Program of China [2006AA02AA404]
  3. International Cooperation Foundation of Guangdong Science and Technology Department of China [2008B050100039]
  4. Specialized Research Fund for the Doctoral Program of Higher Education of China [20090171110077]

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Purpose: To investigate the prognostic significance of prevertebral space involvement (PSI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). Methods and Materials: A retrospective review of data from 506 biopsy-proven, nonmetastatic NPCs was performed. Patients underwent magnetic resonance imaging examinations and received IMRT as their primary treatment. Results: In this series, 161 NPC patients (31.8%) had PSI. Parapharyngeal space (p < 0.001), skull base (p < 0.001), and paranasal sinuses (p = 0.009) were associated with PSI after multivariate analysis. The 4-year overall survival (OS), local relapse-free survival (LRFS), distant metastasis-free survival (DMFS) for NPC patients with and without PSI was 69.1% and 89.2% (p < 0.0001), 83.9% and 96.4% (p < 0.0001), and 71.6% and 89.6% (p < 0.0001), respectively. Multivariate analysis identified PSI as an independent negative prognostic factor for both OS (HR = 1.478-4.380; p = 0.001) and DMFS (HR = 1.389-4.174; p = 0.002). Patients with PSI had similar survival rates in OS and DMFS (p = 0.241 and p = 0.493, respectively) to that of T4 disease, while the differences between PSI and T3 disease in both OS and DMFS were distinctly significant (p = 0.029 and p = 0.029, respectively). Conclusions: For NPC patients treated with IMRT, PSI was found to be an independent prognostic factor for both OS and DMFS. It seems reasonable that PSI should be classified as a T4 disease on the basis of the current American Joint Committee on Cancer staging classification criteria. (C) 2012 Elsevier Inc.

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