期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 81, 期 1, 页码 77-84出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2010.05.013
关键词
Limited-disease small-cell lung cancer; Prophylactic cranial irradiation; Neuropsychological testing; Quality of life; Chronic neurotoxicity
资金
- National Cancer Institute [RTOG U10 CA21661, CCOP U10 CA37422, Stat U10 CA32115]
Purpose: To determine the effect of dose and fractionation schedule of prophylactic cranial irradiation (PCI) on the incidence of chronic neurotoxicity (CNt) and changes in quality of life for selected patients with limited-disease small-cell lung cancer (LD SCLC). Methods and Materials: Patients with LD SCLC who achieved a complete response after chemotherapy and thoracic irradiation were eligible for randomization to undergo PCI to a total dose or 25 Gy in 10 daily fractions (Arm 1) vs. the experimental cohort of 36 Gy. Those receiving 36 Gy underwent a secondary randomization between daily 18 fractions (Arm 2) and twice-daily 24 fractions (Arm 3). Enrolled patients participated in baseline and follow-up neuropsychological test batteries along with quality-of-life assessments. Results: A total or 265 patients were accrued, with 131 in Arm 1,67 in Arm 2, and 66 in Arm 3 being eligible. There are 112 patients (42.2%) alive with 25.3 months of median follow-up. There were no significant baseline differences among groups regarding quality-of-life measures and one of the neuropsychological tests, namely the Hopkins Verbal Learning Test. However, at 12 months after PCI there was a significant increase in the occurrence of CNt in the 36-Gy cohort (p = 0.02). Logistic regression analysis revealed increasing age to be the most significant predictor of CNt (p = 0.005). Conclusions: Because or the increased risk of developing CNt in study patients with 36 Gy, a total PCI dose of 25 Gy remains the standard or care for patients with LD SCLC attaining a complete response to initial chemoradiation. (C) 2011 Elsevier Inc.
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