期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 80, 期 2, 页码 398-402出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2010.02.042
关键词
Breast cancer; Radiotherapy; Radiotherapy timing; Breast-conserving surgery; Endocrine therapy
资金
- Swiss Group for Clinical Cancer Research
- Frontier Science and Technology Research Foundation
- Cancer Council Australia
- Australian New Zealand Breast Cancer Trials Group (National Health Medical Research Council)
- National Cancer Institute [CA-75362]
- Swedish Cancer Society
- Cancer Association of South Africa
- Foundation for Clinical Cancer Research of Eastern Switzerland (OSKK)
Purpose: To evaluate the association between the interval from breast-conserving surgery (BCS) to radiotherapy (RT) and the clinical outcome among patients treated with adjuvant endocrine therapy. Patients and Methods: Patient information was obtained from three International Breast Cancer Study Group trials. The analysis was restricted to 964 patients treated with BCS and adjuvant endocrine therapy. The patients were divided into two groups according to the median number of days between BCS and RT and into four groups according to the quartile of time between BCS and RT. The endpoints were the interval to local recurrence, disease-free survival, and overall survival. Proportional hazards regression analysis was used to perform comparisons after adjustment for baseline factors. Results: The median interval between BCS and RT was 77 days. RT timing was significantly associated with age, menopausal status, and estrogen receptor status. After adjustment for these factors, no significant effect of a RT delay weeks was found. The adjusted hazard ratio for RT within 77 days vs. after 77 days was 0.94(95% confidence interval [CI], 0.47-1.87) for the interval to local recurrence, 1.05 (95% CI, 0.82-1.34) for disease-free survival, and 1.07 (95% CI, 0.77-1.49) for overall survival. For the interval to local recurrence the adjusted hazard ratio for <= 48, 49-77, and 78-112 days was 0.90(95% CI, 0.34-2.37), 0.86 (95% CI, 0.33-2.25), and 0.89 (95% CI, 0.33-2.41), respectively, relative to >= 113 days. Conclusion: A RT delay of <= 20 weeks was significantly associated with baseline factors such as age, menopausal status, and estrogen-receptor status. After adjustment for these factors, the timing of RT was not significantly associated with the interval to local recurrence, disease-free survival, or overall survival. (C) 2011 Elsevier Inc.
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