期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 77, 期 4, 页码 1266-1273出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2009.09.047
关键词
Parotid glands; Head and neck; TomoTherapy; IMRT; Adaptive radiotherapy
资金
- Bayrisches Staatsministerium fur Umwelt und Ge-sundheit
- DFG Cluster of Excellence: Munich-Centre for Advanced Photonics
Purpose: To assess the impact of interfractional variations of shape and setup uncertainties on the dose to the parotid glands (PGs) in head-and-neck cancer intensity-modulated radiotherapy and image-guided radiotherapy (IGRT). Methods and Materials: Two scenarios were analyzed retrospectively for 10 head-and-neck cancer patients, treated with helical TomoTherapy (Tomo Therapy Inc., Madison, WI): the IGRT scenario and the non-IGRT scenario. The initial dose volume histograms derived from the planning computed tomography (PCT) scan and 120 recalculated dose volume histograms of the PGs of each scenario and of corresponding fractions were compared. Setup errors, cumulative median doses (CMDs) for 6 fractions, overall volumes of the PGs, and volumes that received less than 1 Gy or more than 1.6 Gy per fraction were analyzed. Results: The mean decrease in the PC volume was 0.13 cm(3)/d. There was a significantly higher CMD than initially predicted (mean increase for 6 fractions, 1.13 Gy for IGRT and 0.96 Gy for non-IGRT). The volume that received less than 1 Gy per fraction decreased (mean difference to PCT, 1.36 cm(3) for IGRT [p = 0.003] and 1.35 cm(3) for non-IGRT [p = 0.003]) and the volume that received more than 1.6 Gy per fraction increased with increasing fraction number (mean difference to PCT, 1.14 cm(3) for IGRT [p = 0.01] and 1.16 cm(3) for non-IGRT [p = 0.006]). There was no statistically significant difference between the two scenarios (CMD, p = 0.095; volume that received <1 Gy per fraction, p = 0.896; and volume that received >1.6 Gy per fraction, p = 0.855). Conclusions: In the analyzed group the actual delivered dose to the PGs does not differ significantly between an IGRT and a non-IGRT approach. However, IGRT in head-and-neck cancer intensity-modulated radiotherapy is strongly recommended to improve patient setup. (C) 2010 Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据