4.7 Article Proceedings Paper

EARLY PREDICTION OF OUTCOME IN ADVANCED HEAD-AND-NECK CANCER BASED ON TUMOR BLOOD VOLUME ALTERATIONS DURING THERAPY: A PROSPECTIVE STUDY

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2008.08.024

关键词

Head and neck cancer; Perfusion; Imaging; Radiotherapy

资金

  1. NCI NIH HHS [P01 CA059827, 3P01 CA59827] Funding Source: Medline

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Purpose: To assess whether alterations in tumor blood volume (BV) and blood flow (BF) during the early course of chemo-radiotherapy (chemo-RT) for head-and-neck cancer (HNC) predict treatment outcome. Methods and Materials: Fourteen patients receiving concomitant chemo-RT for nonresectable, locally advanced HNC underwent dynamic contrast-enhanced (DCE) MRI scans before therapy and 2 weeks after initiation of chemo-RT. The BV and BF were quantified from DCE MRI. Preradiotherapy BV and BF, as well as their changes during RT, were evaluated separately in the primary gross tumor volume (GTV) and nodal GTV for association with outcomes. Results: At a median follow-up of 10 months (range, 5-27 months), 9 patients had local-regional controlled disease. One patient had regional failure, 3 had local failures, and I had local-regional failure. Reduction in tumor volume after 2 weeks of chemo-RT did not predict for local control. In contrast, the BV in the primary GTV after 2 weeks of chemo-RT was increased significantly in the local control patients compared with the local failure patients (p < 0.03). Conclusions: Our data suggest that an increase in available primary tumor blood for oxygen extraction during the early course of RT is associated with local control, thus yielding a predictor with potential to modify treatment. These findings require validation in larger studies. (C) 2008 Elsevier Inc.

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