期刊
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
卷 90, 期 8, 页码 615-621出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09553002.2014.892227
关键词
Cancer stem cells; radiation therapy; radiosensitivity; radioresistance; plasticity; microenvironment; hypoxia
资金
- NIH [R01-CA155693]
- Department of Defense [W81XWH-13-1-0352]
- CPRIT [RP120380]
- MDACC Center for Cancer Epigenetics
- RNA Center-Laura & John Arnold Foundation grant
Purpose: Radiation therapy has made significant contributions to cancer treatment. However, despite continuous improvements, tumor recurrence and therapy resistance still occur in a high proportion of patients. One underlying reason for this radioresistance might be attributable to the presence of cancer stem cells (CSC). The purpose of this review is to discuss CSC-specific mechanisms that confer radiation resistance. Conclusions: We focus our discussions on breast cancer and glioblastoma multiforme (GBM) and conclude that both CSC-intrinsic and CSC-extrinsic factors as well as adaptive responses in CSC caused by irradiation and microenvironmental changes all make contributions to CSC-mediated radioresistance. Our discussions emphasize CSC as novel therapeutic targets in order to potentiate radiotherapy efficacy.
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