期刊
MOLECULAR CANCER
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-015-0291-7
关键词
Insulin-like growth factor-1 (IGF-1); IGF-1 receptor (IGF-1R); IGF-binding proteins (IGFBPs); IGF-1 signaling; IGF-1 regulation; Estrogens; Estrogen receptor (ER); Breast cancer; Mammary tumorigenesis
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
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