期刊
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
卷 18, 期 1, 页码 58-62出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13651501.2013.845218
关键词
Paliperidone; extrapyramidal symptoms; working memory; elderly schizophrenia; risperidone
类别
资金
- Yoshitomiyakuhin
- GlaxoSmithKline
- Dainippon Sumitomo
- Pfizer
- Meiji Seika
- Janssen
- Mitsubishi Tanabe
- Otsuka
- Tokai University School of Medicine
- Eisai
- Lilly
- Astellas
Objective. This study was to evaluate the effects on clinical symptoms and cognitive function of switching the treatment of elderly patients with schizophrenia from risperidone to paliperidone (PAL). Methods. This study was a 12-weeks, preliminary open-label trial. The subjects were 17 inpatients. Their extrapyramidal symptoms (EPS) were assessed using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS), Abnormal Involuntary Movement Scale (AIMS), and Barnes Akathisia Scale (BAS), and their cognitive function was assessed using the Brief Assessment Cognition in Schizophrenia: Japanese language version (BACS-J), and their clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression-Severity of illness scale (CGI-S) at the 0 and 12 weeks. Results. The DIEPSS and BAS significantly improved aft er switching from risperidone to PAL. Furthermore, improvement was found on AIMS. The mean change from baseline in z-score of the digit sequencing task was significantly increased. All items on the PANSS and CGI-S were not significant; however, changes in some cognitive function were correlated with changes in EPS. Conclusions. The results of this study suggest the possibility that switching elderly patients from risperidone to PAL may have improved preexisting EPS, and may also have helped improve working memory.
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