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Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
Mary E. Rinella et al.
JOURNAL OF LIPID RESEARCH (2008)
Transcriptomic and Metabonomic Profiling of Obesity-Prone and Obesity-Resistant Rats under High Fat Diet
Houkai Li et al.
JOURNAL OF PROTEOME RESEARCH (2008)
Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes
Geoffrey T. Gipson et al.
MOLECULAR BIOSYSTEMS (2008)
Inflammatory mechanisms in the regulation of insulin resistance
Herbert Tilg et al.
MOLECULAR MEDICINE (2008)
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Sekar Kathiresan et al.
NATURE GENETICS (2008)
Targeting bile-acid signalling for metabolic diseases
Charles Thomas et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Altered Metabolism of Growth Hormone Receptor Mutant Mice: A Combined NMR Metabonomics and Microarray Study
Horst Joachim Schirra et al.
PLOS ONE (2008)
Detection and identification of novel metabolomic biomarkers in preeclampsia
Louise C. Kenny et al.
REPRODUCTIVE SCIENCES (2008)
Genetic Mapping in Human Disease
David Altshuler et al.
SCIENCE (2008)
Quantitative metabolomics using NMR
David S. Wishart
TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2008)
Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
Christian Gieger et al.
PLOS GENETICS (2008)
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling
Christine T. Ferrara et al.
PLOS GENETICS (2008)
Global transcript profiles of fat in monozygotic twins discordant for BMI:: Pathways behind acquired obesity
Kirsi H. Pietilainen et al.
PLOS MEDICINE (2008)
Plasma fatty acid metabolic profile coupled with uncorrelated linear discriminant analysis to diagnose and biomarker screening of type 2 diabetes and type 2 diabetic coronary heart diseases
Lun Zhao Yi et al.
METABOLOMICS (2008)
Dietary taurine supplementation ameliorates diabetic retinopathy via anti-excitotoxicity of glutamate in streptozotocin-induced Sprague-Dawley rats
Xiaoping Yu et al.
NEUROCHEMICAL RESEARCH (2008)
Elevated plasma free fatty acids predict sudden cardiac death:: a 6.85-year follow-up of 3315 patients after coronary angiography
Stefan Pilz et al.
EUROPEAN HEART JOURNAL (2007)
The ubiquitin-proteasome pathway in health and disease of the nervous system
Ashok N. Hegde et al.
TRENDS IN NEUROSCIENCES (2007)
Metabolome analysis by capillary electrophoresis-mass spectrometry
Maria Rowena N. Monton et al.
JOURNAL OF CHROMATOGRAPHY A (2007)
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
Pengxiang She et al.
CELL METABOLISM (2007)
The use of metabolomics for the discovery of new biomarkers of effect
B. van Ravenzwaay et al.
TOXICOLOGY LETTERS (2007)
Exercise, MAPK, and NF-κB signaling in skeletal muscle
Henning F. Kramer et al.
JOURNAL OF APPLIED PHYSIOLOGY (2007)
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
Douglas E. Befroy et al.
DIABETES (2007)
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
R. M. Salek et al.
PHYSIOLOGICAL GENOMICS (2007)
Defective mitochondrial biogenesis - A hallmark of the high cardiovascular risk in the metabolic syndrome?
Enzo Nisoli et al.
CIRCULATION RESEARCH (2007)
Application of DNA microarrays in the study of human obesity and type 2 diabetes
Guang Sun
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2007)
From exogenous to endogenous:: The inevitable imprint of mass spectrometry in metabolomics
Elizabeth J. Want et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage
Hiroko P. Indo et al.
MITOCHONDRION (2007)
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Fredrik Backhed et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
Olaf Beckonert et al.
NATURE PROTOCOLS (2007)
The importance of free fatty acids in the development of Type 2 diabetes
J. P. H. Wilding
DIABETIC MEDICINE (2007)
High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: An important role for skeletal muscle pyruvate dehydrogenase kinase 4
K. Chokkalingam et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
Leonie K. Heilbronn et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Insulin resistance and low urinary citrate excretion in calcium stone formers
A. Cupisti et al.
BIOMEDICINE & PHARMACOTHERAPY (2007)
Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GUMS and PLS-LDA
Lun-Zhao Yi et al.
FEBS LETTERS (2006)
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh et al.
NATURE (2006)
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
Julie St-Pierre et al.
CELL (2006)
Malabsorption syndrome with and without small intestinal bacterial overgrowth:: A study on upper-gut aspirate using 1H NMR spectroscopy
Lakshmi Bala et al.
MAGNETIC RESONANCE IN MEDICINE (2006)
OMICS-driven biomarker discovery in nutrition and health
Martin Kussmann et al.
JOURNAL OF BIOTECHNOLOGY (2006)
PGC-1α:: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes
S. Soyal et al.
DIABETOLOGIA (2006)
Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets
Jianxiang Xu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
A critical reflection on the definition of metabolic syndrome
Giovanni Federspil et al.
PHARMACOLOGICAL RESEARCH (2006)
Metabolic profiling of livers and blood from obese Zucker rats
NJ Serkova et al.
JOURNAL OF HEPATOLOGY (2006)
Measurement of the energy-generating capacity of human muscle mitochondria: Diagnostic procedure and application to human pathology
AJM Janssen et al.
CLINICAL CHEMISTRY (2006)
A multi-analytical platform approach to the metabonomic analysis of plasma from normal and zucker (fa/fa) obese rats
R Williams et al.
MOLECULAR BIOSYSTEMS (2006)
The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats
RE Williams et al.
MOLECULAR BIOSYSTEMS (2006)
Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients
B Bakalar et al.
CRITICAL CARE MEDICINE (2006)
Chemical inhibition of citrate metabolism alters body fat content in mice
F Isken et al.
HORMONE AND METABOLIC RESEARCH (2006)
Energy metabolism and oxidative stress - Impact on the metabolic syndrome and the aging process
M Frisard et al.
ENDOCRINE (2006)
Metabolomics: Current technologies and future trends
Katherine Hollywood et al.
PROTEOMICS (2006)
Lactate physiology in health and disease
Barrie Phypers et al.
BJA EDUCATION (2006)
Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase
H Yamashita et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)
Clinical applications of microarray-based diagnostic tests
L Wu et al.
BIOTECHNIQUES (2005)
Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens
Y Seki et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2005)
Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
TR Koves et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The burden of mortality attributable to diabetes - Realistic estimates for the year 2000
G Roglic et al.
DIABETES CARE (2005)
Obesity alters gut microbial ecology
RE Ley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Utilizing human blood plasma for proteomic biomarker discovery
JM Jacobs et al.
JOURNAL OF PROTEOME RESEARCH (2005)
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
I Valle et al.
CARDIOVASCULAR RESEARCH (2005)
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
ME Bollard et al.
NMR IN BIOMEDICINE (2005)
Type 2 diabetes: principles of pathogenesis and therapy
M Stumvoll et al.
LANCET (2005)
Metabolomics: Current analytical platforms and methodologies
WB Dunn et al.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2005)
Metabolic syndrome, obesity, and mortality - Impact of cardiorespiratory fitness
PT Katzmarzyk et al.
DIABETES CARE (2005)
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
KF Petersen et al.
PLOS MEDICINE (2005)
A signaling role of glutamine in insulin secretion
CH Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Of mice and not men: Differences between mouse and human immunology
J Mestas et al.
JOURNAL OF IMMUNOLOGY (2004)
Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus - Clinical and biochemical differences
CA Newton et al.
ARCHIVES OF INTERNAL MEDICINE (2004)
Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice
GM Schmid et al.
PROTEOMICS (2004)
Nutritional importance of choline for brain development
SH Zeisel
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2004)
Metabolomic applications of electrochemistry/mass spectrometry
PH Gamache et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2004)
The gut microbiota as an environmental factor that regulates fat storage
F Bäckhed et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
High glutathione turnover in human cell lines revealed by acivicin inhibition of γ-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition
B Hultberg et al.
CLINICA CHIMICA ACTA (2004)
Update on diabetes mellitus
M Korc
DISEASE MARKERS (2004)
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
U Özcan et al.
SCIENCE (2004)
The cellular fate of glucose and its relevance in type 2 diabetes
C Bouché et al.
ENDOCRINE REVIEWS (2004)
Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display
IP López et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and elderly subjects
LI Arwert et al.
NUTRITIONAL NEUROSCIENCE (2003)
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes:: Potential role of PGC1 and NRF1
ME Patti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
VK Mootha et al.
NATURE GENETICS (2003)
Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects
J Nygren et al.
DIABETES (2003)
Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes
G Boden
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2003)
Plasma phospholipid transfer protein activity and small, dense LDL in type 2 diabetes mellitus
KCB Tan et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2003)
Effects of a branched-chain amino acid drink in mania
A Scarnà et al.
BRITISH JOURNAL OF PSYCHIATRY (2003)
Fatty acid composition of serum lipid fractions in type 2 diabetic patients with microalbuminuria
MS Perassolo et al.
DIABETES CARE (2003)
Glutamine and glutamate as vital metabolites
P Newsholme et al.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2003)
Diagnostic criteria for respiratory chain disorders in adults and children
FP Bernier et al.
NEUROLOGY (2002)
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
DE Kelley et al.
DIABETES (2002)
The KEGG databases at GenomeNet
M Kanehisa et al.
NUCLEIC ACIDS RESEARCH (2002)
The BCAA-BCKA cycle: Its relation to alanine and glutamine synthesis and protein balance
M Holecek
NUTRITION (2001)
StAR protein and the regulation of steroid hormone biosynthesis
DM Stocco
ANNUAL REVIEW OF PHYSIOLOGY (2001)
Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise
EE Blaak et al.
DIABETES (2000)
Metabolite profiling for plant functional genomics
O Fiehn et al.
NATURE BIOTECHNOLOGY (2000)
Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle
K Cusi et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients - The Verona Diabetes Study
M Muggeo et al.
DIABETES CARE (2000)
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