期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 63, 期 7, 页码 368-373出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.853665
关键词
Biodegradable; drug release; micro-device
资金
- National Natural Science Foundation of China (NSFC) [50375116]
- National High Technology Research and Development Program of China (863 Program) [2003AA404170]
- Fundamental Research Funds for the Central Universities
A novel controlled drug delivery micro-device was successfully prepared with biodegradable implants based on PLGA by solvent evaporation method. The micro-chambers were fabricated using the UV-LIGA technology. The controlled release process resulted from the design of the micro-chambers and the characteristics of biodegradable polymers. Implant bioactivity was tested using in vitro and in vivo release. The implants kept good shape and cisplatin was homogeneous loaded in the PLGA implants. The precast implants appeared hexagon. With different proportion of PLA and PGA segment, the swelling behavior and the hydrolytic degradation rate of implants became lower due to the increase of PLA hydrophobic segment. In vitro and in vivo drug release behavior was studied using cisplatin as model drug, the implants could control the diffusion of cisplatin. The results demonstrated that this type of controlled drug delivery micro-device could be more potential application in tumor therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据