期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 63, 期 10, 页码 510-517出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2013.854222
关键词
pore size; tissue engineering scaffolds; porosity; immiscible polymer; solvent-free fabrication; GBM cells
资金
- National Institutes of Health [R21EB008573]
- National Science Foundation [CMMI-1131710]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1131710] Funding Source: National Science Foundation
A completely organic solvent-free fabrication method is developed for tissue engineering scaffolds by gas foaming of immiscible polylactic acid (PLA) and sucrose blends, followed by water leaching. PLA scaffolds with above 90% porosity and 25-200 mu m pore size were fabricated. The pore size and porosity was controlled with process parameters including extrusion temperature and foaming process parameters. Dynamic mechanical analysis showed that the extrusion temperature could be used to control the scaffold strength. Both unfoamed and foamed scaffolds were used to culture glioblastoma (GBM) cells M059K. The results showed that the cells grew better in the foamed PLA scaffolds. The method presented in the paper is versatile and can be used to fabricate tissue engineering scaffolds without any residual organic solvents.
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