期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 62, 期 7, 页码 369-376出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2012.706839
关键词
Attapulgite; composite hydrogel bead; drug-release behavior; guar gum; pH-sensitive
资金
- National Natural Science Foundation of China [51003112]
- Jiangsu Provincial Science & Tech. Department [BY2010012]
A novel guar gum-g-poly (acrylic acid)/attapulgite/sodium alginate (GG-g-PAA/APT/SA) composite hydrogel bead with excellent pH sensitivity was prepared via a facile ionic gelation approach and characterized by FTIR and SEM techniques. The effect of APT content on the encapsulation efficiency (EE), swelling ratio, and drug release behaviors of the beads was investigated and the in-vitro release kinetics were also evaluated using diclofenac sodium (DS) as the model drug. The results indicate that the burst release effect of DS drug was eliminated due to the incorporation of APT, and the DS cumulative release was clearly decreased with increasing the APT content.
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