期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
卷 60, 期 8, 页码 562-575出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2010.531809
关键词
microtubular scaffold; nerve tissue engineering; P19 cell; polyhydroxybutyrate; solid liquid phase separation
资金
- Iran National Science Foundation (INSF)
In this study, we fabricated PHB scaffolds by solid/liquid phase separation method. The properties of fabricated scaffolds were investigated using SEM, DMTA, and DSC. Our studies noticed that for an approach to scaffolds that contain tubular morphology and better mechanical properties, the solution should be frozen near crystallization temperature. For in vitro evaluation, the P19 mouse embryonal cell line was used as a model system. Results notice that cells attach and differentiate to the nerve cell. In vitro assay shows that it is a suitable model for use as a platform for neural tissue engineering applications.
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