Effect of Surface Modification of Nano-Hydroxyapatite Particles on In Vitro Biocompatibility of Poly (epsilon-Caprolactone)-Matrix Composite Biomaterials

Three silane coupling agents were employed to modify the surfaces of nano-hydroxyapatite particles. Alamar Blue activity and alkaline phosphatase assay on the surfaces of the modified n-HA/PCL composites were carefully examined. The results showed that the KH792 silane modification had positively impact in interaction between bone marrow cells, and it suggested this KH792 modified composite was basically biocompatible with bone cells of rats.