期刊
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
卷 19, 期 1, 页码 83-93出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1023666X.2014.864488
关键词
Pterostilbene; Characterization; Controlled release; Stability; Vanillin; Chitosan microspheres
资金
- Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei Province Key Laboratory of Molecular Chemistry for Drug, and Innovation Team Funding of Hebei University of Science and Technology
A vanillin cross-linked chitosan microsphere delivery system was established for stabilization and controlled release of pterostilbene. The prepared microspheres were characterized by SEM images, FT-IR spectra, thermogravimetry, and X-ray diffraction. FT-IR spectra results indicated that chitosan was cross-linked by vanillin successfully. Thermal analysis showed that pterostilbene had been totally incorporated into the microspheres and the encapsulation of pterostilbene decreases the rate of degradation and increases the stability. XRD analysis was conducted to confirm the results of DSC analysis. The release rate of pterostilbene from microspheres in pH 3.6 buffer solution could be up to 58.1 % within 48h.
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