期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 550, 期 1-2, 页码 251-268出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2018.08.043
关键词
Aggregate; Particulate; Opalescence; Oligomerization; Conformation; Colloidal stability
Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of the inherent and high aggregation tendency during various manufacturing processes, storage, and administration. Protein aggregates may impact significantly the product quality, safety and/or efficacy. This review is intended to summarize four major aspects of protein aggregation - (1) aggregation mechanisms, (2) aggregation-influencing factors, (3) detection of protein aggregates, and (4) control of protein aggregation based on recent literature in this area.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据