期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 461, 期 1-2, 页码 519-528出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.12.007
关键词
Nanoliposome; Cancer cells; Lecithin; Drug encapsulation
资金
- Syrian Ministry of Higher Education and Aleppo-University
The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound. We demonstrated that liposomal preparations to deliver curcumin increase its bioavailability. Liposomes composed of salmon's lecithin also improved curcumin bioavailability compared to those constituted of rapeseed and soya lecithins. A realtime label-free cell analysis system based on real-time cell impedance monitoring was used to investigate the in vitro cytotoxicity of liposomal preparations. (C) 2013 Elsevier B.V. All rights reserved.
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