期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 472, 期 1-2, 页码 192-201出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2014.06.027
关键词
Monitoring; Pharmaceuticals; Granulation; High-shear; Process analytical technologies
资金
- GlaxoSmithKline
- Natural Sciences and Engineering Research Council of Canada (NSERC)
High-shear wet granulation is commonly used in the pharmaceutical industry to improve powder properties for downstream processes such as tabletting. Granule growth, however, is difficult to predict because the process is sensitive to raw material properties and operating conditions. Development of process analytical technologies is encouraged by regulatory bodies to improve process understanding and monitor quality online. The primary technologies investigated for high-shear wet granulation monitoring include power consumption, near-infrared spectroscopy, Raman spectroscopy, capacitance measurements, microwave measurements, imaging, focused beam reflectance measurements, spatial filter velocimetry, stress and vibration measurements, as well as acoustic emissions. This review summarizes relevant research related to each of these technologies and discusses the challenges associated with each approach as a possible process analytical technology tool for high-shear wet granulation. (C) 2014 Elsevier B.V. All rights reserved.
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