4.7 Article

Influence of particle geometry and PEGylation on phagocytosis of particulate carriers

期刊

INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 465, 期 1-2, 页码 159-164

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ELSEVIER
DOI: 10.1016/j.ijpharm.2014.02.037

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Non-spherical particles; PEGylation; Flow cytometry; Phagocytosis; Macrophages; Geometry

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Particle geometry of micro-and nanoparticles has been identified as an important design parameter to influence the interaction with cells such as macrophages. A head to head comparison of elongated, non-spherical and spherical micro- and nanoparticles with and without PEGylation was carried out to benchmark two phagocytosis inhibiting techniques. J774.A1 macrophages were incubated with fluorescently labeled PLGA micro- and nanoparticles and analyzed by confocal laser scanning microscope (CLSM) and flow cytometry (FACS). Particle uptake into macrophages was significantly reduced upon PEGylation or elongated particle geometry. A combination of both, an elongated shape and PEGylation, had the strongest phagocytosis inhibiting effect for nanoparticles. (C) 2014 Elsevier B.V. All rights reserved.

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