期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 473, 期 1-2, 页码 203-212出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2014.07.009
关键词
Inflammatory bowel disease; Nanoparticles; pH-sensitive; PLGA; Eudragit (R); Curcumin
资金
- Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (F.R.I.A.) (Regis Coco)
Nano-scaled particles have been found to preferentially accumulate in inflamed regions. Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment. Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties. Hence, we evaluated, both in vitro and in vivo, the local delivery of CC using pH-sensitive polymeric nanoparticles (NPs) combining both poly(lactide-co-glycolide) acid (PLGA) and a polymethacrylate polymer (Eudragit (R) S100). CC-NPs significantly enhanced CC permeation across Caco-2 cell monolayers when compared to CC in suspension. CC-NPs significantly reduced TNF-alpha secretion by LPS-activated macrophages (J774 cells). In vivo, CC-NPs significantly decreased neutrophil infiltration and TNF-alpha secretion while maintaining the colonic structure similar to the control group in a murine DSS-induced colitis model. Our results support the use of nanoparticles made of PLGA and Eudragit S100 combination for CC delivery in IBD treatment. (C) 2014 Elsevier B.V. All rights reserved.
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