期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 473, 期 1-2, 页码 501-509出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2014.07.046
关键词
Photosensitizer; Sodium alginate; Phototoxicity; Reactive oxygen species; Apoptosis
资金
- National Natural Science Foundation of China [21244005, 20974130]
- Science and Technology Planning Project of Guangdong Province, China [2012B091100457, 2012B091100356]
Photosensitizer-encapsulated amphiphilic sodium alginate derivative (Photosan-CSAD) nanoparticles were prepared because of their ability to enhance phototoxicity in the photodynamic therapy of pancreatic cancer. These nanoparticles are spherical, 150-250 nm in size as determined by transmission electron microscopy, and have negative zeta potentials. Upon incubation with human pancreatic cancer cells, the Photosan-CSAD nanoparticles showed high fluorescence activity and reactive oxygen species generation, resulting in strong phototoxicity. However, no dark toxicity was observed. Apoptosis played a leading role in the cell death process induced by the Photosan phototoxicity. These results demonstrate that the Photosan-CSAD nanoparticles are a candidate for the photodynamic therapy of pancreatic cancer. (C) 2014 Elsevier B.V. All rights reserved.
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