期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 441, 期 1-2, 页码 721-727出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.10.022
关键词
Lysozyme; CMC; Electrostatic attraction; Nanogels; Drug delivery
资金
- National Natural Science Foundation of China [31071607]
Lysozyme (Ly) and sodium carboxymethyl cellulose (CMC) were used to fabricate nanogels by a convenient method without using any chemical treatment except simple heating to achieve the denaturation temperature of Ly. The prepared nanogels were characterized by dynamic laser scattering (DLS), rheological analysis, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The nanogels are of spherical shape with average hydrodynamic diameter of 241 nm and the swelling ratio of nanogels is about 5. Then 5-fluorouracil was used as a model drug to investigate the entrapment efficiency and release ability in nanogels. It turned out to be that the release in simulated gastric fluid (SGF) was more slowly compared with that in simulated intestinal fluid (SIF), which could protect the 5-Fu in stomach and ensure it released in intestines. (C) 2012 Elsevier B.V. All rights reserved.
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