期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 447, 期 1-2, 页码 213-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.02.037
关键词
NLC; Nanoemulsion; Coenzyme Q10; Skin permeation; Stability
资金
- research platform Characterization of drug delivery systems on skin and investigation of involved mechanisms, University of Vienna, Austria
Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved. (C) 2013 Elsevier B. V. All rights reserved.
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