期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 444, 期 1-2, 页码 70-76出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2013.01.040
关键词
Vitamin B-12; Nanofiber; Transdermal patch; Sustained release
资金
- Ministry of Education [R-265-000-318-112]
- NRF-Technion [R-398-001-065-592]
- A*STAR-BEP [R-265-000-437-305]
- NUSNNI, National University of Singapore, Singapore
Biocompatible PCL polymer nanofiber mediated sustained release of hydrophilic drug and applicability as transdermal delivery system is attempted. This new attempt to investigate water soluble vitamin delivery with hydrophobic polymer nanofiber sustained the release of the vitamin and the method is suited for the transdermal patch applications. The drug loaded fibers were characterized with SEM for morphology, porometer for pore size measurements, mechanical strength calculation and FT-IR for drug load characterization. The contact angle measurement showed surface wettability and controlled release of drug was quantified with UV absorption measurements. To further enhance the release of vitamin, the polymer fiber was plasma treated at different time intervals and made hydrophilic gradually. Since the increased surface area and drug encapsulation in nano-reservoirs can able to release drug in small quantities and in a sustained manner we attempted the release of the energy supplement with nanofibrous delivery mode. (C) 2013 Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据