期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 450, 期 1-2, 页码 241-249出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.04.017
关键词
Bolaamphiphiles; Iron oxide nanoparticles; Magnetic nanoparticles; Nano-drug delivery systems; Targeted drug delivery
资金
- Israel Science Foundation [973/11]
Bolaamphiphiles - amphiphilic molecules consisting of two hydrophilic headgroups linked by a hydrophobic chain - form highly stable vesicles consisting of a monolayer membrane that can be used as vehicles to deliver drugs across biological membranes, particularly the blood-brain barrier (BBB). We prepared new vesicles comprising bolaamphiphiles (bolavesicles) that encapsulate iron oxide nanoparticles (IONPs) and investigated their suitability for targeted drug delivery. Bolavesicles displaying different headgroups were studied, and the effect of IONP encapsulation upon membrane interactions and cell uptake were examined. Experiments revealed more pronounced membrane interactions of the bolavesicles assembled with IONPs. Furthermore, enhanced internalization and stability of the IONP-bolavesicles were observed in b.End3 brain microvessel endothelial cells - an in vitro model of the blood-brain barrier. Our findings indicate that embedded IONPs modulate bolavesicles' physicochemical properties, endow higher vesicle stability, and enhance their membrane permeability and cellular uptake. IONP-bolavesicles thus constitute a promising drug delivery platform, potentially targeted to the desired location using external magnetic field. (C) 2013 Elsevier B.V. All rights reserved.
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