期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 423, 期 2, 页码 554-561出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.11.035
关键词
Doxorubicin hydrochloride; Lipid nanocarrier; Gantrez; Lipomer; Drug loading; Oral bioavailability
资金
- University Grants Commission, Govt. of India
The present study discusses design of doxorubicin hydrochloride (Dox) loaded lipid based nanocarrier (LIPOMER) for oral delivery. High entrapment (>90%) and high loading (38.11 +/- 0.37% w/w) of hydrophilic Dox in lipid nanocarrier of polyglyceryl-6-distearate was achieved using poly(methyl vinyl ether-co-maleic anhydride) (Gantrez (R) AN 119) and a modified nanoprecipitation method. Dox-LIPOMER revealed nanosize (314 +/- 16.80 nm) and negative zeta potential (-25.00 +/- 2.41 mV). Dox-LIPOMER exhibits sustained release in vitro and was influenced by ionic strength of dissolution medium. DSC and XRD studies suggested amorphous nature of Dox in LIPOMER. TEM revealed spherical morphology of Dox-LIPOMER. Dox-LIPOMER was stable up to 12 months at 25 degrees C/60% RH. A 384% enhancement in oral bioavailability compared to Dox solution was observed following Dox-LIPOMER administration at 10 mg/kg body weight. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) assay data of heart and kidney tissues of rats treated with Dox-LIPOMER were comparable with untreated rats. Dox-LIPOMER represents a potential safe drug delivery system for oral administration. (C) 2011 Elsevier B.V. All rights reserved.
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