期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 436, 期 1-2, 页码 771-777出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.07.063
关键词
Prokaryotic cells; Eukaryotic cells; Magnetic chitosan; Magnetic cellulose; Magnetic composite
资金
- National Research project Human Resources 135 [76/2010]
- National Research project Ideas [154/2011]
Preparation and characterization of CS/Fe3O4/CMC composite scaffolds including the morphology, crystallinity, and the in vitro efficacy as antibiotic delivery vehicles as well as their influence on the eukaryotic cells are reported. The results demonstrated that the magnetic polymeric composite scaffolds are exhibiting structural and functional properties that recommend them for further applications in the biomedical field. They improve the activity of currently used antibiotics belonging to penicillins, macrolides, aminoglycosides, rifampicines and quinolones classes, representing potential macromolecular carriers for these antimicrobial substances, to achieve extracellular and intracellular targets. The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner. (c) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据