期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 437, 期 1-2, 页码 80-82出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2012.07.065
关键词
Cyclodextrins; Amphotericin B; Eye drops; Stability; Antifungal activity
资金
- Ministerio of Education
- UCM
- CCAA Madrid [910939]
Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein, a solution of AmB with gamma-cyclodextrin is described as suitable for topical administration as eye drops. This novel formulation is characterised by its ability to solubilise AmB and to maintain its antifungal activity, physicochemical stability and sterility over 30 days. Antifungal activity against Candida albicans was significantly higher (35%) for the new formulation than that obtained with Fungizone (R) based extemporaneous prepared suspension. Optimal 0.1% AmB-10% cyclodextrin formulation remained sterile and with an acceptable osmolarity, pH and particle size for ophthalmic use over 4 weeks. Complexation with gamma-cyclodextrins improved AmB chemical stability compared to the reference eye drops suspension based on Fungizone (R). These results illustrate the feasibility of an ophthalmic AmB formulation easy enough to be licensed or prepared in community and hospital pharmacies. (C) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据