期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 438, 期 1-2, 页码 249-257出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2012.09.007
关键词
Emulsion; Enzymatic catalysis; Oral drug delivery; Skin drug delivery; Solid-in-oil dispersion
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI KIBAN S Grant [24226019]
- Research Fellowships of the JSPS for Young Scientists
Drug delivery systems using a solid-in-oil (S/O) dispersion as a core technology have advanced significantly over the past ten years. A novel, effective and practical preparation method for a S/O dispersion was originally established in 1997 as a tool for enzymatic catalysis in organic media. This oil-based dispersion containing proteins in non-aqueous media had great potential for applications to other research with one of the most successful being its adaptation as a drug delivery system. The history and features of novel processes for preparing S/O dispersions are presented in this article. In addition, recent research into the use of S/O dispersions for innovative oral and skin drug delivery systems is discussed. (c) 2012 Elsevier B.V. All rights reserved.
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