期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 411, 期 1-2, 页码 169-171出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2011.03.037
关键词
Cocrystal; Grinding; Milling; High-throughput; Automation; Solvent drop; SDG; Mechanochemical; Screening
The application of a novel modified planetary mill, with the capacity to process 48 samples in parallel, to the rapid screening of pharmaceutical cocrystals via grinding is demonstrated for carbamazepine/saccharin, caffeine/oxalic acid, and caffeine/maleic acid cocrystals. Milling is performed directly in standard glass vials therefore no vessel decontamination is needed or sample loss occurs. Furthermore, successive sample processing can be employed without the need for additional material, making the system suitable for screening compounds of limited availability. Use of the system in an automated screening workflow of dispensing, milling, and analysis with high-throughput is also discussed. (C) 2011 Elsevier B.V. All rights reserved.
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