期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 413, 期 1-2, 页码 103-109出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2011.04.030
关键词
Hollow microspheres; Bioadhesive microspheres; Glyceryl monooleate; Psoralen
The purpose of this study was to produce hollow and bioadhesive microspheres to lengthen drug retention time in the stomach. In these microspheres, ethylcellulose was used as the matrix, Eudragit (R) EPO was employed to modulate the release rate, and glyceryl monooleate (GMO) was the bioadhesive polymer in situ. The morphological characteristics of the microspheres were defined using scanning electron microscopy. The in vitro release test showed that the release rate of drug from the microspheres was pH-dependent, and was not influenced by the GMO coating film. The prepared microspheres demonstrated strong mucoadhesive properties with good buoyancy both in vitro and in vivo. Pharmacokinetic analysis indicated that the elimination half-life time of the hollow-bioadhesive microspheres was prolonged, and that the elimination rate was decreased. In conclusion, the hollow-bioadhesive synergic drug delivery system may be advantageous in the treatment of stomach diseases. (C) 2011 Elsevier B.V. All rights reserved.
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