期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 418, 期 1, 页码 104-114出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2010.11.048
关键词
Polymer erosion; Mathematical model; Drug delivery
资金
- National Science Foundation [EEC 0552584, EEC 0851519]
- Office of Naval Research-MURI [NN00014-06-1-1176]
Bioerodible polymers have been extensively used as carriers for drug delivery and as scaffolds for tissue engineering. The ability to model and predict erosion behavior can enable the rational design and optimization of biomaterials for various biomedical applications in vivo. This review examines critically the current approaches in mathematical modeling of the erosion of synthetic polymers. The models are classified broadly based on whether they use phenomenological, probabilistic, or empirical approaches. An analysis of the various physical, chemical, and biological factors affecting polymer erosion and the classes of bioerodible polymers to which these analyses have been applied are discussed. The key features and assumptions associated with each of the models are described, and information is provided on the limitations of the models and the various approaches. The review concludes with several directions for future models of polymer erosion. (C) 2010 Elsevier B.V. All rights reserved.
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