期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 66, 期 -, 页码 3-11出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2015.02.016
关键词
Alzheimer; Abeta; Amyloid; Tau; Genetics; Next generation sequencing; PICALM; SORL1; EPHA1; APOE; APP; Vaccine; Secretase; Nicastrin; Presenilin; PSEN1; Neurodegeneration; Dementia
资金
- Wellcome Trust
- Medical Research Council
- National Institute of Health Research
- Alzheimer Society of Ontario
- National Institute of Health
- Canadian Institutes of Health Research
- MRC [MC_G1000734] Funding Source: UKRI
Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid beta-peptide (A beta). Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of A beta produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD). Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of A beta. This review summarises some of the recent molecular and structural work on the role of these genes and the proteins coded by them in the biology of A. We also briefly outline how the emerging knowledge about the pathways involved in A beta generation and clearance can be potentially targeted therapeutically. This article is part of Special Issue entitled Neuronal Protein. (C) 2015 The Authors. Published by Elsevier Inc.
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