期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 420, 期 1, 页码 111-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2011.08.011
关键词
Tanespimycin; 17-AAG; Polymeric micelle; Prostate cancer
资金
- National Institutes of Health [R01 EB007171]
- Utah Science Technology and Research (USTAR) initiative
Polymeric micelles carrying the heat shock protein 90 inhibitor tanespimycin (17-N-allylamino-17-demethoxygeldanamycin) were synthesized using poly(styrene-co-maleic acid) (SMA) copolymers and evaluated in vitro and in vivo. SMA-tanespimycin micelles were prepared with a loading efficiency of 93%. The micelles incorporated 25.6% tanespimycin by weight, exhibited a mean diameter of 74 +/- 7 nm by dynamic light scattering and a zeta potential of -35 +/- 3 mV. Tanespimycin was released from the micelles in a controlled manner in vitro, with 62% released in 24h from a pH 7.4 buffer containing bovine serum albumin. The micellar drug delivery systems for tanespimycin showed potent activity against DU145 human prostate cancer cells, with an IC(50) of 230 nM. They further exhibited potent anti-cancer activity in vivo in nu/nu mice bearing subcutaneous DU145 human prostate cancer tumor xenografts, with significantly higher anticancer efficacy as measured by tumor regression when compared to free tanespimycin at an equivalent single dose of 10 mg/kg. These data suggest further investigation of SMA-tanespimycin as a promising agent in the treatment of prostate cancer. (C) 2011 Elsevier B.V. All rights reserved.
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