期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 391, 期 1-2, 页码 65-72出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2010.02.019
关键词
Needle-free injection; Transdermal drug delivery; ShimaJet (R); Systemic drug delivery; Local drug delivery; High molecular weight compounds
We evaluated a needle-free injector (NFI), which has been studied as an administration device to the subcutaneous tissue, as a device to deliver drugs into skin tissues. ShimaJet (R) used for self-injection of insulin was selected as a spring-powered NFI in this study. Weak (NFI-w) and strong (NFI-s) injectors were evaluated. Rhodamine 6G, as a model compound, was injected onto the skin surface of hairless rats and the skin distribution and amount released from the skin of the compound were followed. A modified nozzle (able to inject at an angle of 45) was prepared in addition to the conventional dedicated nozzle. The spring constants, nozzle shapes and penetration enhancer,1-[2-(decylthio)ethyl] azacyclopentane-2-one (HPE-101), affected not only the skin distribution, but also the release profiles of rhodamine 6G. In addition, the release profiles of rhodamine 6G after injection using NFI-w or NFI-s obeyed diffusion-controlled or membrane-controlled kinetics, respectively. This difference was probably due to the skin site (depth) of rhodamine 6G delivered by the NFI. Furthermore, HPE-101 increased the retention time of rhodamine 6G in the epidermis. The present results suggested that an NFI can be a useful tool for enhanced drug delivery into skin. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
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