期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 402, 期 1-2, 页码 254-257出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2010.09.025
关键词
Nanosponges; Ultrasound; Oxygen release; Cyclodextrin; Hydrogel
资金
- Italian Ministry of Education, University and Research (MIUR) Italian government
- University grant commission (UGC) India
Three types of cyclodextrin nanosponges were synthetized cross-linking alpha, beta or gamma cyclodextrin with carbonyldiimidazole as cross-linker. Nanosponges are solid nanoparticles previously used as drug carriers. In this studies cyclodextrin nanosponges were developed as oxygen delivery system. For this purpose the three types of nanosponges suspended in water were saturated with oxygen and in vitro characterized. The nanosponge safety was tested on Vero cells. Their ability to release oxygen in the presence and in the absence of ultrasound (US) was determined over time. Oxygen permeation through a silicone membrane was obtained using a beta-cyclodextrin nanosponge/hydrogel combination system. Nanosponge formulations might be potential gas delivery systems showing the ability to store and to release oxygen slowly over time. (C) 2010 Elsevier B.V. All rights reserved.
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