期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 401, 期 1-2, 页码 32-40出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2010.09.005
关键词
Alzheimer's disease; Acetylcholinesterase inhibitor; Butyrylcholinesterase inhibitor; Cymbopogon citratus; Essential oil; Microemulsion; Phase diagrams
资金
- Thailand Research Fund through the Royal Golden Jubilee PhD Program [5.G.CM/50/D.1]
- Graduate school, Chiang Mai University
In the present study, essential oils of three edible Thai plants, Cymbopogon citratus (Gramineae), Citrus hystrix (Rutaceae) and Zingiber cassumunar (Zingiberaceae) were comparatively tested for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities using Ellman's colorimetric method. C. citratus oil exhibited the highest activity with IC50 values of 0.34 +/- 0.07 mu l/ml and 2.14 +/- 0.18 mu l/ml against BChE and AChE activity, respectively. It was further investigated whether microemulsions of this oil could be obtained. The effects of type of surfactant and co-surfactant as well as pH and ionic strength on the phase behavior of the oil/water system were investigated. Brij 97, Triton X-114, Tween 20 and Tween 85 were employed as surfactant whereas ethanol and hexanol were used as cosurfactants. The size analysis, electrical conductivity measurements and cholinesterase inhibition assays were done in selected microemulsion. The results revealed that the type and concentration of surfactant and co-surfactant exhibited a distinct influence on the C. citratus oil microemulsions. Moreover, the inhibitory activities of the microemulsion formulation were remarkable. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据