期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 392, 期 1-2, 页码 72-77出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2010.03.029
关键词
Transdermal penetration; Liniment; Geniposide; Mice
资金
- Innovation and Science and Technology of Yunnan Province [2008AD015]
- National Natural Science Foundation of China [30973896, 90713043, 30801523]
- National Key New Drug R&D Program for the 11th Five-year Plan of China [2009ZX09103-301, 2009ZX09502]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0754897] Funding Source: National Science Foundation
Zhongtong Caji, a kind of liniment, is a traditional Chinese medicinal formula that is widely used for clinical treatment of inflammation and sprains. In this study, the principal effective compound of this formula, geniposide, was used as a criterion to represent the transdermal permeability of the whole formula. A passive diffusion of Zhongtong Caji through the stratum corneum was discovered by an in vitro experiment. The dosage-content relationship detected in subcutaneous tissue after in vivo drug administration was further evidence of its permeation. Blood analysis after different dosages showed that the geniposide could be absorbed and accumulated by subcutaneous tissue within 1 h after drug administration, and it would be eliminated by blood circulation 1 h after drug treatment. (C) 2010 Elsevier B.V. All rights reserved.
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