期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 365, 期 1-2, 页码 89-99出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2008.08.027
关键词
Biodegradable; Thermosensitive hydrogel; Sol-gel-sol transition; Degradation; In vitro drug release
资金
- National 863 Project [2007AA021902]
- National Natural Science Foundation [NSFC20704027, NSFC30370550]
- Sichuan Prominent Young Talents Program [07ZQ026-033]
- Sichuan Key Project of Science and Technology [2007SGY019]
- Chinese Key Basic Research Program [2004CB518807]
In this work, a series of biodegradable triblock poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers were successfully synthesized by ring-opening copolymerization, and were characterized by H-1 NMR, FT-IR, GPC, and DSC. Aqueous solutions of PIECE copolymers underwent thermosensitive sol-gel-sol transition as temperature increases when the concentration was above corresponding critical gel concentration (CGC). Sol-gel-sol phase transition diagrams were recorded using test tube inverting method, which depended on hydrophilic/hydrophobic balance in macromolecular structure, as well as some other factors, including topology of triblock copolymers and solution composition of the hydrogel. As a result, the sot-gel-sol transition temperature range could be varied, which might be very useful for its application as injectable drug delivery systems. The in vivo gel formation and degradation behavior was conducted by injecting aqueous PIECE solution into KunMing mice subcutaneously. In vitro degradation behavior, in vitro drug release behavior, and cytotoxicity were also investigated in this paper. Therefore, owing to great thermosensitivity and biodegradability of these copolymers, PECE hydrogel is believed to be promising for in situ gel-forming controlled drug delivery system. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据