期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 374, 期 1-2, 页码 58-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2009.03.010
关键词
Hydrogel; PEG; Disulfide; Biodegradable; DDS
资金
- Korea Healthcare technology RD Project
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A084285]
- Ministry of Science and Technology [M10534030004-08N3403-00410]
- Korea Health Promotion Institute [A084285] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과06A1501, 2005-2001099] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We developed a polyethylene glycol (PEG)-based biodegradable hydrogel through disulfide crosslinking of polyethylene oxide sulfide (PEOS). The crosslinking rate was highly dependent on temperature, and incubation at about 40-50 degrees C was required for efficient crosslinking. The crosslinked PEOS hydrogel showed glutathione-dependent dissolution and corresponding controlled release of a model drug-fluorescein isothiocyanate (FITC)-labeled dextran-because the disulfide bond, the main linker, is selectively degraded in response to the high concentration of glutathione. The temperature-sensitive crosslinking and the hydrogel formation have the potential for use as an injectable biogel precursor, which was confirmed by in situ gel formation in mice. (C) 2009 Elsevier B.V. All rights reserved.
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