期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 378, 期 1-2, 页码 215-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2009.05.058
关键词
Microbubbles; Oxygen; Ultrasound; Chitosan; Hypoxia
资金
- Italian Ministry of University [PRIN 2006]
- Ricerca Sanitaria Finalizzata Project 2006 of Regione Piemonte
Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics. (C) 2009 Elsevier B.V. All rights reserved.
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