期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 404, 期 C, 页码 1-8出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2014.07.024
关键词
Epidermis; Melatonin; 6-hydroxymelatonin; AFMK; 5-methoxytryptamine; Melanocytes
资金
- NIH [1R01AR056666-01A2, 1S10OD010678-01]
Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This production depends on race, gender and age. The highest melatonin levels are in African-Americans. In each racial group they are highest in young African-Americans [30-50 years old (yo)], old Caucasians (60-90 yo) and Caucasian females. AFMK levels are the highest in African-Americans, while 6(OH)M and 5MT levels are similar in all groups. Testing of their phenotypic effects in normal human melanocytes show that melatonin and its metabolites (10(-5) M) inhibit tyrosinase activity and cell growth, and inhibit DNA synthesis in a dose dependent manner with 10(-9) M being the lowest effective concentration. In melanoma cells, they inhibited cell growth but had no effect on melanogenesis, except for 5MT which enhanced L-tyrosine induced melanogenesis. In conclusion, melatonin and its metabolites [6(OH)M, AFMK and 5MT] are produced endogenously in human epidermis and can affect melanocyte and melanoma behavior. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据