期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 380, 期 1-2, 页码 25-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2009.06.023
关键词
Drug release; Kinetics; Modeling; Swelling; Hydrogels
资金
- University of Helsinki (Development of Nano Sciences/HENAKOTO [700036]
A cellular automata approach for modeling swelling-controlled drug release is presented. In the model, a drug release device is divided into a square grid space. Each cell in the grid contains information about the material, drug, polymer or solvent in that domain. Cells are allowed to change their state according to statistical rules designed to mimic physical phenomena. Diffusion and swelling are modeled by a random walk of mobile cells, and kinetics of chemical or physical processes by probabilities of conversion from one state to another. The model is applied to drug release from a swelling binary polymer/drug device. The effect of simulation parameters on the drug release profiles and the locations of erosion and diffusion fronts are considered. The model was able to produce realistic simulations and is proposed as a new tool for the design of controlled release devices. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据