期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 357, 期 1-2, 页码 280-285出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2008.01.025
关键词
cyclodextrin; emulsion solvent diffusion; nanocrystals; indomethacin
Cyclodextrins (CyDs) were employed as protective stabilizers for the preparation of surfactant-free nanocrystals of indomethacin (IMC) by using the emulsion solvent diffusion method. The effect of changing the type and concentration of CyDs on the formation of IMC nanocrystals was investigated. Dispersions were freeze-dried to characterize the size, shape, nanoparticle yield, crystallinity, and dissolution behavior of the obtained particles. Submicron-sized particles of IMC with average diameters in the range of 300-500 nm were obtained by incorporating alpha-, beta-, or gamma-CyD in the outer phase of the primary emulsions. Quantitative determination demonstrated that more than 80% of IMC was recovered as fine particles smaller than 0.8 mu m. The powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) analyses of the freeze-dried samples confirmed the polymorphic change of IMC to the meta-stable form. A significant enhancement in the dissolution rate of IMC nanocrystals was observed when compared to the commercial powder. (c) 2008 Elsevier B.V. All fights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据